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Trends Mol Med 2018 Mar 15 pii: S1471-4914(18)30031-5 doi: 10.1016/j.molmed.2018 02.007. [Epub ahead of print]

Humań Endogenous Retroviruses in Neurological Diseases.

Kury P¹. Nath A². Creanae A³. Dolei A⁴. Marche P⁵ Gold J^Q. Giovannoni G⁷. Hartuno HP³. Perron H⁶.

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Abstract

The causes of multiple sclerosis and amyotrophic lateral sclerosis have long remained elusive. A new category of pathogenic components. normally dormant within human genomes. has been identified: human endogenous retroviruses (HERVs). These represent ~8% of the human genome. and environmental factors have reproducibly been shown to trigger their expression. The resulting production of envelope (Env) proteins from HERV-W and HERV-K appears to engage pathophysiological pathways leading to the pathognomonic features of MS and ALS_: respectivel>'. Pathogenic HERV eiements may thus provide a missing link in understanding these complex diseases. Moreover their neutralization may represent a promising strategy to establish novel and morę powerful therapeutic approaches.

PMID: 29551251 DOI: 10.1016/i.molmed 2018 02.007 Free fuli text