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Lancet Neurol. 2015 Apr:14i4i 406-19. doi 10.1016/S1474-4422(14)70305-9

Role of the innate and adaptive immune responses In the course of multiple sclerosis.

Hemmer B¹. Kerschensteiner M². Korn T³.

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Abstract

Multiple sclerosis is a chronic disease of the CNS that leads to substantial disability in most patients. The early phase is characterised by relapses and the later phase by progressive disability. Results from immunological. genetic_: and histopathological studies and treatment trials have shown that the immune system plays a key part in the disease course. Findings from animal models and immunological studies of patients with multiple sclerosis suggest a change in the involvement of the immune system during disease initiation and progression. These findings suggest that a peripheral immune response targeting the CNS drives the disease process during the early phase. whereas immune reactions within the CNS dominate the prcgressive phase. These concepts for the differential involvement of immune responses in the early and progressive phase of this disease have important implications for futurę research in the pathcgenesis and treatment of multiple sclerosis.

PMID: 25792099 DOI: 10.1016/S1474-4422C14)70305-9 [lndexed for MEDLINE]

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