15 Fuzja błon SNARE

As docking proceeds. the increased curvature and lateral tension induce the approaching bilayer leaflets to fuse. thereby exposing the bilayer interior.

As the vesicle approaches its target membranę, the SNAREs begin zipping together (docking) from their N-termini. which draws the two membranes toward each other to form trans-SNARE complexes.

3 The two bilayer leaflets that were . originally farthest apart are brought together to form a new bilayer. ▼

5 The fusion porę expands as the now fused membranę relaxes yielding cis-SNARE complexes.

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ormation: The continuing SNARE-induced lateral tension causes membranę breakdown. resulting in the formation of a fusion porę.

Figurę 12-76 Model for SNARE-mcdiated vesiele fusion. Here the R-SNARE and the O-SNAREs are schcmatically

represented by red and bluc worms. [ Aftcr a drawing by Chen, Y. A. and Scheller. R.H.. Naturę Rev. Mol. Celi Biot. 198 (2001).]