Headache
Confusion
Anorexia
Low blood pressure
Liver:
t Synthesis of acute phase proteins
Eniarged draining lymph nodes
Ascending
lymphangitis
Local cellulitis Pain Redness Swelling
Flushing
T Respiratory ratę T Heart ratę, flow murmur
Adrenal release of glucocorticoids and catecholamines
Release of insulin from panereas
Bonę marrow:
t Production and mobilisation of neutrophils
Hypothalamus:
Change in temperaturę set point
Fever
Sweating
Neuro-endocrine and autonomie stress responses
Skin rupture
Local infection Bacteria
Tissue damage
Inflammatory mediators and cytokines
Phagocytosis Cytokine production yasodilatation T Local vascular
yasodilatation Neutrophils
T Local vascular — permeability
Macrophages
^ permeability t Leucocyte influx
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