Life Cycle of Onchocerca volvulus PLoS Medicine
L3 Larvae
L1 Larvae
Blackfly (genus Simulium) takes a blood meal and L3 Larvae enter bite wound.
Infective Stage
Migrate to blackfly’s head and proboscis
HUMAŃ STAGE
Humań
Subcutaneous
tissue
Adults in
subcutaneous
nodules
Blackfly (genus Simulium) takes a blood meal and ingests microfilariae.
Microfilariae penetrate blackfly’s midgut and migrate to thoracic muscles
BLACKFLY STAGE
Adults produce unsheathed microfilariae that typically are found in skin and lymphatics of connective tissues, but also occasionally in peripheral blood, urine and sputum.
Diagnostic Stage
Based on an a figurę created for the CDC.
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