11 Biosynteza hemu(1)

Carte

xtd

c>do

-OOC—CH,—CH,—C— CaA SucrliurU-oA

KjN—CII,—COO-(:ivclnc

~    ^ L

HC-l jl—CH

^n-r-

co,—H

^2H' w—7    Proloporphyrtn DC

"OOC—Clfc—CH,—C—CHg—NH, S-AmlnoU-iulInlr Kld <ALA|

JHL

⁴T^_n.L_n^T^:

- Y¹

HC=f >p=CH

P M Hemu

HjC—I    H ^C"'

P M

Protoporplurlnogcn IX

|xrph:łm:-.r»ę«=

•yntha**'

2 CO,

phyiiaopn

H.C CH,

-,-0

NH, »

PorpfiobllliKyion (PBC)

*4 NH,

Figura 26-39 Tb* oicrał fuilwjy of hc-nc btoiyuibafc.

Ł-Amiitofctuliu: ac*l (Al A) 8 ijnUascal n Ibr m.>:doi*lnon by ALA syiliasc Al A (It/T) lcava tle ratccbofKWon arxl 1» CDBieited to PBC. lour molccuScs c< wtoch o:<uknv lo lora a porpbyrln Iteg-Tbe oexl Iwo rcaellaos lnvo(ve oaUaUia d Ua pyrrolc rui* sabstiucats yaUug proloporpbyrlitogen IX wSdk

MrmUjin b aoccoiponud by 111 transport baci lalo Ibc mllocboidrloi Allcr ottfetlaa ol Ibc melhylroe groups Untiig lic py rrolti lo jtdd proloporpftynn IX ItrrociclaUBc ci tatro, lic uscrUon <*Fc^:' to yaU łcac A. P. M and V. mpccUw-lj. reprcscril acetyl profłcuyl natbyl aal vayl (—Cl fc—Cl l;i grosps Calonu cnglśaug as lic carbcóy I tf osp ć< acrUlr arc roi