17 BiosyntezaÎramidu

O

3-ketosphinganine synthase

O

H—CHo—

CH₂—CH₂—(CH₂)₁₂—CH_a

H₂N—C—H CHoOH

NADPH + H'

NADP

OH

CH—CH₂—CH₂—(CH₂)j₂—CH₃ H₂N—C—H CH9OH

O

II

R—C—SCoA

1=

?^H

CoASH

CH—CH₉—CH.,—(CH₉)_Å‚9—CH₃

II    I

R—C—NH—C—H

CH₉0H

faji

fadh₉

OH H

I I

<|^H—C=(j?—(CH₂)₁₂—CH₃ R—C—NH—C— H    H

O

?

ch₂oh

FigurÄ™ 25-89 The biosynthesis of ceramide (.V-acvlsphinj*osine).