202413
Infection with Mycobacterium leprae can result in different clinical forms ot leprosy
There are two polar forms, tuberculoid and lepromatous leprosy, but several intermediate forms also exist
Tuberculoid leprosy
Lepromatous leprosy
Organisms show florid growth _in macrophages_
Low infectivity
High infectivity
Granulomas and local inflammation. Peripheral nerve damage
Disseminated infection.
Bonę, cartilage, and diffuse nerve damage
Hypergammaglobulinemia
Normal serum immunoglobulin levcls
Normal T-cell responsiveness. Specific response to M. leprae antigens
Low or absent T-cell responsivoncss. No response to AL leprae antigens
Figurę 11-6 part 1 of 2 Immunobiology, 6/e. (O Garland Science 200$)
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