8 Transporter karnitynowy

8 Transporter karnitynowy



1.    The acyl group of a cytosolic acyl-CoA is transferred to carnitine. thereby releasing the CoA to its cytosolic pool.

2.    The resulting acyl-carnitine is transported into the mitochondrial matrix by the transport system.

3.    The acyl group is transferred to a CoA molecule from the mitochondrial pool.

4.    The product carnitine is returned to the cytosol.

Cytosol    Inner    Matrix

mitochondrial membranę

Carnitine -

' carnitine palmitoyl transferase I

R—C—Carnitine II

O


O

R-C-SCoA


H-SCoA


O

- Carnitine r-c-SCoA


carnitine palmitoyl transferase II

R—C—Carnitine    H-SCoA

II

O

Figurę 25-11 Transport of fatty arids into the mitochondrion.


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