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FIGURĘ 26-17 Addition of the poly(A) Mil lo ilu* primary RNA tran-script of oukaryotos. Pol II synthosizos RNA boyond tho segment of the transcript containing the cleavage signal sequences, including the highly conserved upstream sequence (5')AAUAAA. (Y) The cleavage signal sequence is bound by an enzyme complex that includes an en-donuclease, a polyadenylate polymerase, and several other multisub-unit proteins involved in soquence recognition, stimulation of cleav-age, and regulation of the length of the poly(A) taił. (2, The RNA is cleaved by the endonuclease at a point 10 to 30 nucleotides 3' to (downstream of) the sequence AAUAAA. 3 The polyadenylate polymerase synthesizes a poly(A) taił 80 to 250 nucleotides long, begin-ning at the cleavage site.
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