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■mii Ctearance: II

PRINCIPLE OF TUBUEAR RFABSORPTION LIMITATION (Tm) USINC CLUCOSE AS EXAMPEE

tubule; it is fully reabsorbed and nonę appears in urine

At Tm

Concentration of glucose in plasma, and consequently in flltratc, is just suffident to saturate rcabsorptive capacity ot tubule

RENAL PHYSIOLOGY

Above Tm Concentration of glucose in pląsmo and consequrntly in tiltrate, exceeds reabsorptive capacity of tubule: glucose appears in urine

400    600

Plasma glucose (mg/dl >

Figurę 6.6 Renal Hanoung of Geucose----

-.ucos* is Eillered al Ihe glomerulus and reabsorbed by the proximal rosę appears in the urine. Therelore, |he renal clearanr e o( glucose •jjąjc. Normally, no glucose appears in the urine becausc all ol the will increase as Ihe plasma concenlration of glucose increases. -■~ed glucose is reabsorbed. However, as the plasma concentration gtucose is increased (e.g., as tan occur in diabetes mellitus). glu-

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