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ENDOCRINE PHYSIOLOGY

Growth Hormone

Increased linear growth

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Decreased adiposity

Increased organ size

Increased lean body mass

J. Perkins

•jlPN

Figurę 8.7 Growih Hormone

Growth hormone's major physiological effect is to stimulate growth and devek>pment in children and adolescenls. It ałso plays an impor-tant role łn regulating overall body metabolism. Growth hormone produces many of effects through the generation, and then subse-quent action of somatomedins such as insulin-likc growih factor (IGF). Amino acids, glucose and FFA exert their effect on GM secre-tion via somatostatin. Amino adds inhibit somatostalin release linerease GH secretionl whereas glucose and FFA stimulate somatostatin release (inhibit GH secrelion). Abbrevtations: HA. Free farty acids; GH, growth hormone; CHRH, growth hormone-releasing hor monę.

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