Penphera) blood ves$ei
) Efferent ; lymphatic I vessel
Activaled
Tcell
E-orP- E-orP- Inteorin
selectm seleclin (LFA-1 or
Ugand . I VLA-4) v
ICAM-1 1 orVCAM-1
High endoihelial venule in tymph node
Endothelium at Iho site of inlecbon
ŚTcełl |
Ligand on |
Function of receptor |
[ homing receptor |
endothelial celi |
ligand pair |
L-seleclin
L-seleclin
ligand
Adhesion of naive T cells lo high endothelial venule inlymphnode
E-orP-
seledin
LFA-1 (P2 inlegrin) or VLA-4 (J)| integnn)
ICAM-1 orVCAM-1
Initial weak adhesion of effector and memory T cells to cytokine-aciivated endothelium al peripheral sile olinfecton
Slabie arresl on cytokme-acłwaled endothelium al peripheral site of infection