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Dircctious: Eacli of (lic luinibcred ilcuis or incoinplete stutemcnts iii i.liis seel/on is followed by answcrs or by coniplelions of llie

slatfincnl. Sclccl (lic ONI¹'. Icllcrcd nnswer or complction liiat is BEST in eaoii case.

fl! • 'The conscqucnce/s ordrug elimiiintion whicli sliow/s non-expotential ”snturalion”(zero order) kinetics is/arc:

A) (lic ilura(ion of ącliun is slrougly dependent on (lic dosc f£0)ilie ilrug isreinoved at a constant ratę (liat iundependent of plasma ciiuccnlratioii C) according to (his kinelics^thanol, pli cny toin and suljgjdate are climinatcd D) A&C <12. Alropinc likc efTccts inclnde'    " ¹    ^

dry moutli, constipatioitfJS) mydriasis, urinary retcntion C) dcci case in łieart contractility andvasodilationfTl) A&B E) A&B&C <13. Whicli slalcmeut about antidepressants is/arc false?

/^tricyclics aro less sclcctivc (lian SSRIs mianserine andmirtazi-pineareantagonists ofaIpha-2 receptors in the ens

SSlUs liave acliicYcd widespread usc bccausc of llieir high eQec(iv.uiess ii/alncinds of depression newer MAO inhibitors inhibit (hc isofonn A in a revcrsiblc nianner flSfiB&D _;    ' ^J

■ 44. Inlialation ahaćslhdtjcs:    1 _

may cause cardiovajciilar depression /®With Iow blood-gas partition coefBcients produce sia D) A&B ©jA&B&C cd as antiinflammatory cmigs?

B) diclophenac C) i eiecoxib D) B&C . E)A&B&C

l^nacti vc at neutrai pl-l

can generale loxic melaboliles j>JSgpid induction and rccoYery 6f ani esthesia mr. Whicli oftheNSAJD are inainly u;

(\f ■& (£) aspirin ¹    ^ PPls^

A) inuibit irrcvcrsibly (hc H+/K+-1 TPasc H^avc long Tjj E) A&B&C

' 'hc false statement about doxycyolinc and minocycline is (hat they ar::

<

B) a!

iduce

CTSTweak bases, they accumulate in the acid environment „

uicy uccumuiaie in mc aciu cnvironment

A) widely distrihuted throughout tl{e body    aimost complctely ab* orbed from the GI tract / C) Łlmost caĄletely excreted by the

kidney D) binding to (lic 30S baiiterial ribosomc .0) long acting.Ooi '6-18 hours)    S--*'

roduced by: *

e trący cl inc    Ol erythromyci i all    _

ktdncy li) binaing to mc jud oacienai er    lcpatotoxicily as a sidc effect may ibe prc

rifainginę |ł) ketokonazolc j CVlel

n-l antagoniśts are uscd as sole therapy in the case of:

> A) broncliial asdnna B) systemie anaphyiaxis . angiocdcrna CDJurticaria £) all

.Oⁱ

ring"ch

30 Imlicatc whicli sidc efTccts of ACE inhibitors sliould be expecled during chronical use of these drugs p /Śf^dccreased serdmK71cvel B)‘ inereased serum glucosc levcl C) incrcased serum cholesterol Icvel D) inereased sauin K⁺ and crralinlnc levds E) B&C are conect    ,

51. lnhibitioii of potassiuin oulward repolarizing current is the main mechniism of action of antiarrhythmic drug :

A) procainamide B) dolctilidc C) Yerapamiij D) flecainide E) lidocaine ■ Slow infusion of NE at ratę lOpg/min will:

A) incrcase pulsc ratc 13) dccreasc diastolic pressure C) inerease p:ripiieral resistance D) decrcase pulsc ratę fi. 1‘rcRiiaii^.women willi liypeitensinn sliould not bc treated wijh:

C AtiiiallJlWopa B) hydralnzfne losartwi U) A«h are correct E) B&C are correct

SAniidiabclic drugs whicli docs not induceseverehypoglycęrn]ais/are:___    _ .

Al inetforinin BI acarbose . C) glyburide D) repaglinide ^ A& B

E) C&D are correct

C / E *|5ŚA.) inetforinin B) acarbose Tliyroxiiie (T4):

docs not rcncli tiuclcus receptors B) hns short half-lifc, about 21i 'S^can not bc given orally .D) is produced by co

lolGUC

El A&D arc correct

Atleution! Awncialc the Ihcrapcutic in^r*‘ions with the most proper opio.d drue: /    , i_^_VńAAM)At1

...... ^    Clg^Mt^foi^id J&ssśtfjj

56. Diarrhca. (pj A) imltrexonc

57. Cough.(^ U) dcxlromethorphan

C) pcnlazoęhie u) ioperam.de E) nonc

ofT3

— Alt

4

irohepl

&)

AUenlioul Asiuculc Ilu; ucii^^mnlnijeceptor with the proper drug;

Aniagonislof 5HT-3 rn-epiors.^    AjitagpnistoFDAjecc

A) sinnatriptnn B) ergotaminę C) mSocloprarimle¹¹' ^jonSisćtron E) cyprolieptadine

•5 11 T./0 fikani**    bitclun?

ganiał estrogen receptors ngonist/antagonist (SERM). ^    Blocker of androgen receptor. 6

A) anastruzolc B) flutamidc C)ialoxifene D) finasteride E) dinazol ^h,eus* atneer    Td. mh-

Attenlion! Associnie tlić action on the hneteria willi thunost proper chento Jicrapcutic (antibiotic, synthetie):

^lt-ritlil^{, ,};^,iil' sff^{cl 1} III'......bw g    ^pSącleriocidal effec. on agrol

Ji) mcUouidazolc B) jclindninycin* 'O gciuai^UTT^ D) A&B E) nonę *

Aitentiuii! Assucialc Ilic lliciapcutic indicaiions willi llie musi proper bela t locker(sj3_

<> \ Uuugestivc igajt l.idmc. _i^:.,    bk llypcitension. GI, 1*U> t»- 67. ilypeilhyroidism. <*v

A) pmpniuulol U) bisoprolol C) alenolul U) esnioloi E) uli

Attcniimi! Associatc llie nicchanistp uf action with llie appropriate drug uscd in ircalment of coronary hcari disea fe. 68. NO donor.    ^asc:

'*69. Calriuin diaiinel bkickuig Uiu^.

S 70. Mctabolic modulMur.

A) an ilfot idc B^isosoi bidę inoiionitraie    c)fiopidog(cl

\C*    ^    Tłifctks

d.ureHic    KVf(v c.

''D.^diltia: citi^E) ^Bnctazidine