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(A) ethpsuximidę (B) Phenobarbital (C) yigabatrin fDj clonazepam (E) yalproic acid . 40 Which br the following drugs próduce tHeiV^arma^~l^gic effect bv interactinp With^ł intraceilular receptora?

(A) leyotjiyroxine (B) yitamin D (C) estrogens (D) glucocorticoids (E) alhof the drugs -

&B (E) all

44. The ćlinical effectiyeness of a drug depends on its:

fA) maximaJ efficacy    r (C) potenc

are correct 45. If a drug elimination is of first order:

■“^A^ą constant amount of drug is eliminated in unit time (B) the capacity of metabolic process is limited (C) the danger of drug toxicity is higher flfflfhe ratę of elimination is directly proportionate to the drug concentration (E) A&B&C are correct

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" 46. Actiyation of beta'2 receptgr is characteristic feature of: •

(A) dopamine (B) norepinephrine (C) epinenhrine (D) A&B&C (E) Nonę of them

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- 47: A drug combination with high risk of adverse effects is: *

_% (A) gemfibrozil+cTólestyrarnine (B) simvastadne+chólestyfaminę (C) niacin+colestipol (D)

' •• simvaststine+fenobibrate (E) lovastatin+ezetimibe

>»48tBisphQsphonatesfeg. Alendronate') are used in the treatment of:    '    . ■ i

fAl^^teoporesis (BI Paget disease (C) hypercalcemia ofmalignancy (D) A&B are correct (E) all are correct

-» 4^ Second generation of HI receptor antagonist is:

(A) promethazine (B) ęromolyn (C) dimenhydrinate (D) clemastine^|^yy|^^

A The inhihition of D2 recepto^ hv rlasdę^l-f^wftleptins-rftp. rhlnmrnmam^ d^not

Pcause: (A) antipsychotic effect (BI inhibition of yomiting (C) hyperprolactinemi*^drops in blood pressure (E) symptoms of Parkinson diseas.

Sl.atypical neuroleptics(olanzapine) differ fiom classical with respect to:

£A)the action on particular symptoms (BYThe effect on negatiye symptoms of schizophrenia (C) efScacy in nonresponsive patients (D)side effects e)all arę.

52. all of the following anticancer drugs are cfilLspecifio_cexcept:

■ fA) cisplatin (B)docetaxel (C) paclitaxei (D) bleomycin

53.decide when pharmacoeconomic analysis of the cost-effectiveness type is indicated:

(B)the new drug is cheaper and kas worse clinical outcome results the new drug is.nhftaper and bas hetter rlinical outcome results

(D) the new drug is cheaper and has the same clinical outcome results

(E) the new drug is costlier and has worse clinical outcome results

Mjwhich of the following effects of morphine is of central origin:    olfyy¹^

^(Ajmyosis (B) urinaryretention (C) hypotension (D)constipation (E) bronchoconstriction

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