3582361538

3582361538



!Q


Leptin


WAT


1


Obesity


Exercise

DNA

Irisin

FNDC5 is cleaved to produce irisin


Irisin reaches WAT and BAT via circulation


10



Energy storage


Diabetes


O2 CO2

Unidentified receptor

Mitochondria

Irisin

binding

Energy expenditure


Weight loss


lmproved glucose homeostasis and insulin sensitivity



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