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VSV G mutants replicate efficiently.

If VSV G mutants are to be considered for oncolytic virotherapy, they should first be able to replicate efficiently. VSV G mutants were therefore tested for their ability to replicate on L929 cells (Figurę 1). Despite mutations in the surface glycoprotein, all mutants replicated as efficiently as wild-type VSV regardless of multiplicity of infection (MOI). We also tested M protein mutant Mmsir replication and observed that it could also