Biotechnology in Oral Care

Martyna Adamska Mateusz

Kręcisz

A few words about



Introduction



Etiology and pathogenesis of oral
problems



The periodontal diseases



Current routes to control and prevent
dental plaque formation

Dental caries and periodontal diseases



Affect many people in various age



Poor hygene of oral cavity is the the
cause



Dental plaque - the interplay
between plaque bacteria and the
host tissues

Periodontal diseases



Meticulous of gingival flora to anaerobic
bacteria



Numbers of bacteria are the risk factor



P. gingivalis, B. forsythus, and T. denticola
– chronic periodontitis



A. actinomycetemcomitans – rapidly
periodontitis



Individual host risk factors

Prevention and control



Meticulous oral hygiene and the
mechanical removal of dental plaque
from all tooth surfaces



Fluoride



Antimicrobial agents



Enzyme systems

Fluoride



Only one clincally accepted anticaries
agent for routine use



Maintain of low concentration of fluoride
in plaque



Fluoride water (0.1 – 1 ppm)



Fluoride toothpaste (1000 – 1500 ppm)
used twice a day



Small devices placed on tooth releasing
fluoride

Antimicrobial agents



Few antimicrobial agents have been
successfully formulated into commercial
products



Among these are three mouth rinses



chlorhexidine (CHX)



Cetylpyridinium chloride (CPC)



Essential oils



Two toothpastes containing triclosan



With coopolymer



Zinc nitrate

Enzymes



Minor role in treatment of oral
diseases



Current enzyme products have not
been proven to prevent or reduce
dental plaque formation

Effects of poor hygiene of mouth

Enzyme Systems

• Glucan,
• Fructan hydrolase,
• Dextranase,
• Mutanase,
• Lactoperoxidase,
• Krill enzymes.

Vaccines and Other Immunogenic Routes to Reduce

Bacterial

Infections and Prevent Oral Disease

• Anti caries vaccine

• Controversial !!

• Costs,
• Antigen 1/11
• clone the genes encoding selective

antibodies

• monoclonal antibody to P. gingivalis

Replacement Therapy and the Use of

Pro- and Prebiotics

• This strain of S.

mutans has been
successfully implanted
in rodents and
resulted in reduced
levels of caries.

• bacteriocin-like sub-

stances

• to prevent oral

malodor

Antimicrobial Peptides

• Natural

antimicrobial
peptides,known as
defensins.

Phage-Encoded Enzymes and

Proteins

• The concept of

cloning genes

• Producing

therapeutic or
pharmacological

DZIĘKUJEMY ZA UWAGĘ ;)

and now it's time for a

movie

http://www.youtube.com/wat
ch?v=rKFVadkgan0