Immunology final II Questions:

21) As complement is activated by complexes of antibody coated bacteria, bystander

lysis of nearby host cells is prevented by….

22) Complement activity is restricted by all of the following EXCEPT

23) A deficiency of complement proteins or in their regulators can result in

24) The ability to make antibody with the same antigen specificity but different Fc

regions

25) Allergy symptoms are produced when antigen binds IgE or FR on

26) One amino acid difference in the Fc region of the different human g chains is the

epitope recognized by the anti-

27) If a B cell tumor is monoclonal, it can be differentiated from normal B cells of the

same person by its unique membrane Ig

28) Multiple myeloma is a cancer which has arisen from a

29) A germinal center is where B cells

30) Somatic recombination occurs

31) In order for NK cells to do ADCC, the must bind…

32) NK cells kills their targets in ADCC using,

33) Most cells release their granule contents to stimulate inflammation in response to

34) Successful immune responses to bacteria which resist phagocytosis because of a

polysaccharides capsule depends on the products of

35) Successful immune response to bacteria which adhere to mucosal surfaces in order to

initiate infection depends on production of

36) FcgRI bonds on with highest affinity to

37) Phagocytosis

38) Effector functions of complement include all of the following EXCEPT

39) Lymphocytes acquire their antigen specificity

40) Inflammation does not involve

Answers:

21) D - proteins on host cell membranes that inhibit MAC formation

22) D - LPS in the outer membrane of Gram negative bacteria that inactivates C3b

23) E - All of the above

24) D - Increases the effector functions of Ig molecules

25) C - Mast Cells

26) A - Allotype

27) C - Idiotype

28) D - plasma cell

29) B - divide in response to antigen

30) B - in the progenitor cell as it is becoming a B cell

31) A - Antibodies to virus proteins expressed on infected cell membranes

32) D - perforins and granzymes

33) A - antigen binding to IgE on mast cell FcR

34) D - opsonizing antibodies

35) C - neutralizing antibodies

36) A - antigen bound IgG₁ and IgG₃

37) A - can be stimulated by antigen binding to complement or antibody

38) E - presenting antigen to B cells

39) B - before they encounter antigen

40) D - secretion of antibodies

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