4 Biosynteza triacylogliceroli(1)

o

CHo—OH

C=0

I

CH₂—O—PO5^-

Dihydroxyacetone phosphate

NADH + H⁺

dihydroxyacetone phosphate acyltransferase

9 r

R—C—SCoA    H—SCoA

CHo—O—C—R

c=o

CH0—O—PO5"

Acy 1-di hyd roxyacetone phosphate

V

glycerol-3-phosphate

dehydrogenase

^ NAD⁺

NADPH + H⁺

acyl-dihydroxyacetone phosphate reductase

K* NADP+

O

CHo—OH

I '

HO—C—H

I

glycerol-3-phosphate

acyltransferase

CHo—O—PO3-

Glycerol-3-

phosphate

⁰ ^ ^

II    ▼

R—C—SCoA    H—SCoA

CHo—O—C—R

I

HO—C—H

I

CHo—O—PO§“

Lysophosphatidic acid

O

R’—C—SCoA

l-acylglycerol-3-phosphate

acyltransferase

^ H—SCoA

O

O

Phospholipid

O

R—C—O—

2-Monoacylglycerol

(from intestinal digestion)

CHo—O—C—R

II    I ’

R—C—O—C—H

CH₂—O—PO§~

Phosphatidic acid

phosphatidic acid phosphatase

O

II

O    CHo—O—C—R

II    I •

R—C—O—C—H

I

CHo—OH

1,2-Diacylglycerol (DAG)

O

II

<— R —C—SCoA diacylglycerol acyltransferase •—► H—SCoA

O

II

O    CHo—O —C—R

II I “

R—C—O—C—H    O

I    II

CH₂—O—C—R"

Triacylglycerol

Figurę 25-42 The reactions of triacylglycerol biosynthesis.