2

CH,

ooc—ch₂ —i—oh₂ —ch₂—

OH

1 2

3|    4    6

OH

Mevalonate

ATP

ADP

mevalonate

5-photiphotmnrtferaM*

Kinaza mewalonianowa

CH,    O

ooc—ch₂ —c—ch₂ —ch₂—o—p—o oh    o

5-Phosphomevalonate

pho*phomevnlonato

kinase

ATP

ADP

O

CH_S

O

ooc—ch₂—c—ch₂—ch₂—o—P—O—P—O’

OH    ⁰ o

5-Pyrophosphomevalonate

pyrophospho-

mevalonate

decarboxylase

ADP

CH,

O O

OOC—CHo —C—CH, —C H₂—O—f>—0—P—O

0“ O"

3-Phospho-5-

pyrophosphomevalonate

CH₃ CH₂=C—(

pyrophospho- mevalonate	co2,	p.
dccarboxylii8c H3	\	)	0
_ru ,_CT	j _o_	>_O-	-p-
	(	r	1 o

Activated

isoprenes

AMsopentenyl pyrophosphate

ch₃

o

o

I    X X

CH₃—C=CH—CH₂—O—P—O—P—O'

o^- A~

Dimethylallyl pyrophosphate

FIGURĘ 21-35 Comersion of movalonato to activatcd isoprcnc units. Six of theso activatod units combino to form squalene (soo Fig. 21-36). The leaving groups of 3-phospho-5-pyrophosphomevalonate are shaded pink. The bracketed intermediate is hypothetical.