lewulino

Glicyna i kwas glutaminowy jako prekursor porfiryn

(a)				[(	1 O O r
(	:oo-			(	:h2
(	h2		CoA-SH	(	'H,	co2
<	'H2 + < l—S-CoA	pHa—NHa zoo	._9 ,		>—o	9
1			f> -aminolevulinate •yntha*c	V \	:h—ńh;i	ć-aminol«vuhnute synthasc
(	)			(	:oo
Succinyl-CoA		| Glycine |		a-Amino-0- ketoadipate_

COO-

Ćh₂

<?h₂

c=o

j?

nh₃

6-Aminolevulinate

ciułania U*- 1 -ocmiaJdcKydc aminomutase

(b)

coo

CH*

COO

I

ch₂

CHo

I ♦

hc-nh₃

c=o

tRNA^c,u

Glutamyl-tRNA⁰¹" FIGURĘ 22-23 Biosynthosis ot «S-aminolcvulinate. (a) In mammals and other higher eukaryotes, 5-aminolevulinate is synthesized from glycine and succinyl-CoA. The atoms furnished by glycine are shown

HC-NH,

COO

Glutamate I

tRNA^Głu

glutnmyl-tRNA syn tlw lane

AMP + PP,

J_

NADPH

NADP⁺ tRNA^clu

J_

glutiimyl-lRNA

rcduclasc

COO

CHo

CHo

I ♦

HC—NH₃

C=0

H

Glutamate 1-semialdehyde

in red. (b) In bacteria and plants, the precursor of 8-aminolevulinate is glutamate.

Biosynteza kwasu 5-aminolewul i nowego - prekursora porfiryn