IMG 67 (4)

Cryptopatches (CPs)

CPsarfloosfhorganizMl clisters of ippromuUły 1000 cdk locatcd at the basc óf tht intestinal epithdial

CPs arr romprised primarily of thra wU types: lineage nurkfr negativf (lirr)c-kir celb, dtndritic cefls (DCs), ind \ascolar cdi adhcskn makak (VCAM)-1⁺ stromal cdk.

Functbns:

1.    Severalstudiessuggestthat CPsaresitesforthe generation of Intraeplthellal T lymphocytes.

2.    The lirrc-ki? CP cefls may be responsible for organlzing lymphoid structures In the intestine, andCPsmaybeprecursorstoILFs