IMG 59 (4)

How different are gastro-intestinal and respiratory mucosal immune systems?

TdMe 1. Comparisons of secondary lymphoid organs

Feature	NALT	PP	BAL	1 ^s
Follicle-assodated epithelium	■f	+		:
M cells	•f	+	+	_
Intra-epithelal l/mphocytes	♦	+	+	-
Genminal centers	♦	+	+	+
Dendritic cels	+	+	+	+
Macrophages	+	♦	+	+
HEV-PNAd	+	+	+	-
MAdCAM-l	+	+	»	“
T: B-cell ratio	09	0.2	0-7	u
CD^4: CD®^4 ratio	-14-	Ł0-

BAŁT, bronchus-associated lymphoid tissue; NALT, nasal-associated lymphoid tissue.

1.    Immunization via orał route results in induction of predominantly mucosal antibodies

2.    Immunization via intranasal route results in induction of serum and mucosal antibodies