37300 IMG 60 (2)

How different are gastro-inłestinal and respiratory mucosal immune systems?

T4Je 1. Compaiisons ofsecandary lymphoid argans
Feature	NALT	PP	BAL	Sph	!!n
Fblide-assodated epitheliun	♦	+	+	_
M cells	+	+	+	_
Intra-epitheial lymphocytes	+	+	+	-
Gemninal centers	+	+	+	+
Dendritic cels	+	+	+	♦
Macrophages	' +	+	+	♦
HEV-PNAd	+	♦	+	-
MAdCAM-l	•f	♦	1	-
T: B-cell ratio	Q9	0.2	07	[ 16
CD^4: CD^84 ratio	-14-	5.0	-14-1	-
BAŁT, bronchus-assooated lymphoid tissue; NALT, aasaJ associated l^ro-
phoid tissue.

1.    Immunization via orał route results in induction of predominantly mucosal antibodies

2.    Immunization via intranasal route results in induction of serum and mucosal antibodies