20470 IMGP4957

Wilms’ tumour

•    Wilms¹ tumour (WT; nephroblastoma), a kidney ncoplasm, is one of the most frequentły occurring solid tumors of childhood.

*    I.oss of function of tumour suppressor gen es has been implicatcd iii the developmcnt of WT, and the Wilms' tumour suppressor gene WT1 (at chrom osom e 1 lpl3) was the second tumour suppressor gene to be doned. aftcr the retinoblastoma gene RB-1.

W Tl plays an essential role in kidney development, but is mutated in only approsimately 20% of WTs, which suggests that further lesions and genętic loci are involved in Wilms¹ lumourigenesis.