72632 IMG 02 (2)

Characteristic

Mast Cełls

Basophils

Eosioophils

Origin of precursor

Major sito of maturation

Maturę cells in circulation

Maturo celts recruited into lis* sues from circulation

Maturo cells residing in connec-tive tissue

Protiferative ability of maturo cells

Life span

Major developmental factor (cytokinel

Expression of FcrRI

Major granule contents

C034 hematopoietic progenitor cells

Connectwe tissue No

No

Yes

Yts

Weeks to months Stern celi factor

High levels

Histaminę, heparin and/or chon* droitin sulfate, proteases

CD34 hematopoietic progenitor cells

Bonę marrow

Yes (0.5% of blood leukocytesl

Yes

No

No

Oays

IL-3

High levels

Histaminę, chondroitin sulfate, protease

CD34* hematopoietic progenitor cells

Bonę marrow

Yes (17% of blood leukocytesl

Yes

Yes

No

Days to weeks

IL-5

Low levels

Major basie protem, eosino* phil cationic protein, pean idases, hydrolases, łyso-phosphofipase

Abbrevialions: FcrRI. Fet receptor type I; IL-3, interleukin-3.

Modified from Costa JJ, PW Wolier, and SJ Galii. The cells of the allergic response. JAMA 278:1815-1622. Copyright 1994, American Medical

Associatioa