1851734592

Phenethyl isothiocyanate

Inducing thc Fas and Fas ligand expression

Highcr ROS gcncration¹⁷⁰¹ Glutathionc dcpletion^17,1

Reduce HER2, STAT3, and PARP PM*

N AD*/ATP dcpletion¹⁷⁴¹ PreventingHIF protein^{,^,|}

Inhibit SOS-1, PKC, ERK1/2, and Rho A I⁷*' Induction of mitochondria caspase Cascade and theJNK'⁷’*

Lesserexpression of NF-kB^,aoł

Lesser phosphorylation ratę of EGFR/AKT pathway^18,1

Preventingthe HDAC¹*¹¹ Decrease expression of CRM1^|H21

Uprcgulate the 8-oxo-deoxy guanine and pH2AX foci

Induction of felToptosis^,M,

Suppression of BcI-2 and XIAP protein Ievels¹⁸⁶¹