7227192283
VIII. ABILITY TO EVADE HOST IMMUNE RESPONSE (CONTD)
IMMUNE EVASK)N BY TUMORS
F ailure to produce tumor antigen
Anogenłoss varvar*of tumor ceł
Mulat tons m MHC genes for antigen proces słng
or gerres needed
Classl
MHC -drtfciert tumor ceł
Lackof
Tcell
recognition of tumor
Lack of Tcell
recognmon of tumor
Productlort of immunosupprevUve protełns or expressłon of mfilbitory celi surtace protełns
Inhtotory Ugand Inhłbtory recepor
Inhlbition of T celi actlvat(on
f lfwr» 7-40 MmJMtnrm by wf•• ł> tumor* «vwł» lim n<maH> ryłtwo Tumor* nw mnuw iwpormwi Iry k«»j «pnwtai ol onboano
a mw> >Mlouomp<rM*y tan%*m 9AHC) mcłacuk* or by prutAłdng <™«i-„.„miM (yTnMnm or łonnd* nur* a* PD-11 lor W*błtnry raonptcrn or> 1 ord* (Fwń*«ai Irwn Allm AK, LkHiiwhi AH, Pilni 8: Cnlkilot and Mil* <lv Hvrunnlri0y. Tth ml, PWrlr^W*, VI© Srundan, 2012J
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