SYNTEZA CHOLESTEROLU
O
O
O
C CoA
S
H3C
O
CH2
H3C
+
CH2
C CH3
HO
CoA
S
CH2
CoA
S
COO-
acetoacetylo-CoA 3-hydroksy-3-metyloglutarylo-CoA (HMG-CoA
acetylo-CaA
2NADPH + H+
O
O
reduktaza HMG-CoA
O
O
+
O
O
P P
P P
O-
O O-
O
O-
CoA + 2NADP+
O-
O- O-
dimetyloalilopirofosforan
pirofosforan izopentylu
PPi
COO-
CH2
PPi
O O
C CH3
HO
O
P P
CH2
O-
O
O- O-
CH2OH
pirofosforan geranylu
mewalonian
pirofosforan izopentylu
ATP
PPi
ADP
O
O
ATP
P
O-
ADP
O P O
O- O-
ATP
pirofosforan farnezylu
NADPH + H+
NADPH + H+
ADP + Pi + CO
pirofosforan farnezylu
2
CH2
NADP+
NADP+
PPi
C CH3
O
CH2
O
SKWALEN
H2C O-
O P O P
O- O-
pirofosforan izopentylu
EPOKSYD SKWALENU
LANOSTEROL
O O
NADPH + H+
CH4
H3C
CH4
C CH CH2 O O O-
P P
NADP+ CH4
H3C
O- O-
HO
dimetyloalilopirofosforan
CHOLESTEROL