Name........................................................................................... Group A 30.10.2008.

1.What organism is most likely responsible for bacterial meningitis in infants during the first month of life:

a) Enterococcus faecalis

b) Staphylococcus aureus

c) Streptococcus agalactiae

d) Streptococcus pneumoniae

2.Virulence factors of S.pneumoniae include:

a) M surface protein

b) Capsules

c) Deoxyribonuclease

d) CF (clumping factor)

3. Most gonococcal strains that produce disseminated diseuse:

a) are sensitive to killing by normal human serum

b) are A-H-U-auxotrophs

c) do not contain LOS

d) are relatively resistance to penicillin

4. First day of life, watery exudet and hyperemia. What is causative agent:

a) N. gonorrhoeea

b) no infected agent - silver nitrate susceptibility

c) S. epidermidis

d) B. pertussis

5. Several Neisseria species are a part of the normal flora (commensals) of the human upper respiratory tract. Which of the following statements accurately describes the significance of these bacteria?

a) As a part of the normal flora, Neisseriae provide a natural immunity in local host defense.

b) As a part of the respiratory flora, they are the most common cause of acute bronchitis and pneumonia

c) Commensal bacteria stimulate a cell-mediated immunity (CMI)

d) Normal flora such as nonpathogenic Neisseriae provide effective nonspecific B-cell-mediated humoral immunity.

6. High ASO titers point to:

a) S.aureus induced infection experienced in the past

b) S.pyogenes

c) S.pneumoniae

d) S.saprophyticus

7. A 57-year-old man arrives at the emergency room complaining of weakness, fatigue and intermittent fever that has occured for several weeks. The patient had a valvular prosthesis implanted five years previously. Physical examination reveals petechiae on the chest and stomach. Blood cultures grew catalase-positive, coagulase-negative cocci. The gram-positive organisms failed of ferment mannitol, and their growth was inhibited by novobiocin. What is the most likely infectious agent?

1. Staphylococcus aureus

2. Staphylococcus epidermidis

3. Staphylococcus saprophyticus

4. Streptococcus pneumoniae

8. A 32-year-old woman became ill four days after the onset of her menstrual period. She presented in the emergency room with fever, elevated white blood cell count (16.000/mm³), and a rash on her trunk and extremities. She complained of fatigue, vomiting and diarrhea. She had recently eaten at a fast-food restaurant, but otherwise had prepared all her meals at home. The patient described most likely has:

a) staphylococcal food poisoning

b) scalded skin syndrome

c) infection with a Staphylococcus saprophyticus

500. toxic shock syndrome

9. Bacteriological filters are used for sterilization of:

a) infusion liquids

b) medicines

c) some kind of bacteriological medium

d) all of above

10. Indicate definition of pasteurization:

a) sterilization in Koch apparatus

b) sterilization by UV

c) sterilization in the autoclave

d) heating of material at 65-80ºC for 30 min.

Name........................................................................................... Group B 30.10.2008.

1. The virulence factors N.meningitidis responible for or thought to faciliate adherence to the nospharyngeal mucosa are:

a) fagella and spores

b) exotoxins and enterotoxins

c) pili and IgA 1 protease

d) outer membrane proteins (OMP)

2. Several days after an unprotected sexual encounter, a healthy 21-years old male develops pain and pus on urination. A Gram stain reveals gram-negative diplococci. Which of the following structures is most responsible for adherence of the offending microbe to the urethral mucosa?

a) capsule

b) fimbriae

c) flagella

d) the F pili

3. Enterococci induce most frequently:

a) food poisoning

b) diseases of respiratory system

c) urinary tract infections

d) veneral diseases

4. MRSA denotes:

1. staphylococci not stained by Gram technique

2. methycillin resistant S.aureus

3. encapsulating S.aureus

4. S.epidermidis strains resistant to antibiotics

5. A 51-year- old man was admitted to the hospital: unresponsive, with epileptiform movements, fever and stiff of his neck. Chest examination reveled lobar pneumonia. Because of the fever and unconsciousness, lumbar puncture was done promptly to examine the CSF: had a heavy concentration of gram-positive cocci in pairs (diplococci), the most likely microbial etiology of his infections is:

a) Staphylococcus aureus

b) Streptococcus pyogenes

c) Streptococcus pneumoniae

d) Staphylococcus epidermidis

6. S. aureus exfoliative toxins:

a) peeling of mammalian cell membranes and thus cell lysis

b) are important causes of toxic shock syndrome in menstruating women

c) cause bullous impetigo

d) act as virulence factors in staphylococcal pharyngitis, requiring prompt antitoxin administration

7. Streptococcus agalactiae is also known by its Lancefield group which is:

a) group A

b) group B

c) group C

d) group D

8. What antigen is most useful in identifying nephritogenic strains of Group A streptococci which may induce glomerulonephritis?

a) capsular antigen

b) cell wall carbohydrates

d) M proteins

d) outer membrane proteins

9. Plasma sterilization can't be used for:

a) surgery devices

b) metals (gold, silver, platin)

c) drugs and dressing

d) none of above

10. Which of the following processes does not kill endospores:

a) autoclaving

b) pasteurization

c) incineration

d) heating in 180ºC for 30 min.

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