Name:………………………………………..……Group 1
16.03.2007
1. Campylobacter microorganisms may be transmitted to man through:
a) milk and meat products
b) tick vector
c) broken skin
d) sexual contact
2. In Vibrio cholerae, the causative agent of cholera, is best described by which of the following statements?
a) cause of gastroenteritis, reservoir in birds and mamonals, optimal growth at 42°C
b) have tree serotypes: Ogawa, Inaba, Hikojima
c) human pathogen, sucrose negative, causes gastrointestinal diseases primarily from ingestion of cooked seafood
d) may be diagnosed by rapid urease test
3. In the treatment of Helicobacter pylori infection following antibiotics may be used
a) amoxicillin
b) clarythromycin
c) metronidazole
d) all the above
4. Diagnosis of leptospiroses involves testing of:
a) throat swab
b) urine
c) pus
d) feces
5. Which laboratory test is the most usefue for diagnosis of Lyme disease
a) culture of microorganism on blood agar
b) detection of IgM/IgG antibodies to spirochets
c) swab from erythrema migrans stained with Gram-method
d) VDRL - assay
6. The probable cause of the relapsing nature of relapsing fever caused by Borrelia recurrentis is:
a) the sequential appearance of new antibiotic resistant variants
b) successive appearance of new antigenic variants
c) ability to activate of dormancy spores
d) periodic hormonal fluctuations in the host
7. A 30-year-old male patient was seen by the emergency service and reported a two-week history of a penile ulcer. He noted that this ulcer did not hurt. Which one of the following conclusions/actions is most valid?
a) Draw blood for a herpes antibody test
b) Even if treated, the lesion will remain for months
c) Failure to treat the patient will have no untoward effect, as this is a self-limiting infection
d) Perform a dark-field examination of the lesion
8. For which of the following organisms is there no animals reservoir?
a) Francisella tularensis
b) Pasteurella multocida
c) Treponema pallidum
d) Brucella melitensis
9. For which of the following organisms is human disease typically acquired by drinking contaminated unpasterized milk?
a) Brucella abortus
b) Francisella tularensis
c) Pasteurella multocida
d) Treponema pallidum
10. Which of the following organisms is typically transmitted sexually?
a) Brucella suis
b) Yersinia pestis
c) Treponema pallidum
d) Pasteurella multocida
Name:………………………………………..……Group 2
16.03.2007
1. Which of the following statements best describes Cmpylobacter jejuni?
a) cause of gastroenteritis, reservoir in birds and animal, can grow at 42°C
b) only human pathogen, causes gastrointestinal diseases primarily from ingestion of seafood
c) human pathogen, produces heat - labile, extracellular toxin
d) have three serotypes: Inaba, Ogawa, Hikojima
2. V. cholerae, the causative agent of cholera is best isolated using which one of the following media
a) Lőfflers medium
b) Lőwenstein - Jensen medium
c) Mannitol salt agar
d) thiosulfate citrate bile salts sucrose medium
3. The patient has been admitted to the hospital because of bledding duodenal ulcer. In culture from gastric biopsy samples urease - positive, curved bacteria was isolate. The most likely causative agent is:
a) Campylobacter jejuni
b) Helicobcter pylori
c) Helicobacter fetus
d) Vibrio cholerae
4. Which of the following microorganisms is usually transmitted by contaminated woter
a) Borrelia recurrentis
b) Leptospira interrogans
c) Treponema pallidum
d) Borrelia burgdorferi
5. In treatment of Lyme disease the following antibiotics are used:
a) doxycycline
b) erythromycin
c) ceftriaxone
d) all the above
6. The probable cause of the relapsing nature of relapsing fever caused by Borrelia recurrentis is:
a) the sequential appearance of new antibiotic resistant variants
b) successive appearance of new antigenic variants
c) ability to activate of dormancy spores
d) periodic hormonal fluctuations in the host
7. A 30-year-old male patient was seen by the emergency service and reported a two-week history of a penile ulcer. He noted that this ulcer did not hurt. The laboratory reports that the Venereal Disease Research Laboratory (VDRL) test performed on the patient is reactive at a dilution of 1:4 (4 dils). The patient also reports to you that he has recently been diagnosed with hepatitis A. Which one of the following actions would be most appropriate?
a) Order a confirmatory test such as the fluorescent treponemal antibody (FTA) test
b) Order a rapid plasma reagin (RPR) test
c) Perform a spinal tap to rule out CNS syphilis
d) Repeat the VDRL test
8. Yersinia pestis, the causative agent of plague, is enzootic in the United States west of the one-hundredth meridian. Human plague can be bubonic or pneumonic. What is the primary epidemiologic difference between the two clinical forms pf plague?
a) Age of the patient
b) Geographic location of the animal vector
c) Health of the animal vector
d) Route of infection
9. P. multocida is a very common organism and is best described by which of the following statements?
a) Commonly inhabits the canine respiratory tract and is an occasional pathogen for humans; strongly urease-positive
b) Pits agar, grows both in carbon dioxide and under anaerobic conditions, and is part of the normal oral cavity flora
c) Typically infects cattle, requires 5 to 10% carbon dioxide for growth, and is inhibited by the dye thionine
d) Typically is found in infected animal bites in humans and can cause hemorrhagic septicemia in animals
10. B. abortus, one of the three species causing brucellosis, a possible bioterrorism agent, is best described by which of the following statements?
a) Commonly inhabits the canine respiratory tract and is an occasional pathogen for humans; strongly urease-positive
b) Manifests different biochemical and physiological characteristics, depending on growth temperature, and causes a spectrum of human disease, most commonly mesenteric lymphadenitis
c) Pits agar, grows both in carbon dioxide and under anaerobic conditions, and is part of the normal oral cavity flora
d) Typically infects cattle, requires 5 to 10% carbon dioxide for growth, and is inhibited by the dye thionine
Name:………………………………………..……Group 3
16.03.2007
1. A family routinely consumed unpasteurized milk, claiming “better taste”. Several members experienced a sudden onset of crampy abdominal pain, fever, and a bloody diarrhea. Campylobacter jejuni was isolated and identified from all patients. The treatment of choice for this type of enterocolitis is which of the following?
a) Ampicillin
b) Campylobacter antitoxin
c) Erythromycin
d) Ciprofloxacin
2. Cholera develops due to:
a) production of cholera toxin
b) adherence of bacteria to cells of small intextine epithelium
c) both of the above
d) genetical predisposition of the host
3. Which of the following is the most effective noninvasive test for the diagnosing of Helicobacter infection
a) culturing of stomach biopsy samples on enrichment medium
b) detection of H. pylori antigen in stool
c) culturing of stool samples on selective medium
d) rapid urease test
4. Which of the following diseases is not a tick - born disease
a) Lyme disease
b) Relapsing fever
c) Tularemia
d) Leptospirosis
5. Erythrema migrans is the clinical stage characteristic for
a) Relapsing fever
b) Lyme disease
c) Syphilis
d) Campylobacter - infections
6. The probable cause of the relapsing nature of relapsing fever caused by Borrelia recurrentis is:
a) the sequential appearance of new antibiotic resistant variants
b) successive appearance of new antigenic variants
c) ability to activate of dormancy spores
d) periodic hormonal fluctuations in the host
7. Leptospira interrogans most commonly attach
a) the central nervous system
b) the kidneys
c) the liver
d) all above organs
8. A 30-year-old male patient was seen by the emergency service and reported a two-week history of a penile ulcer. He noted that this ulcer did not hurt. Which one of the following test combinations for syphilis is most appropriate?
a) FTA-Abs (IgG)/FTA-Abs (IgM)
b) RPR/culture of the lesion
c) RPR/ FTA-Abs
d) VDRL/RPR
9. Brucella is pathogenic for humans and animals. Which one of the following statements best characterizes this organism?
a) It causes spontaneous abortion and has tropism for placental tissue due to the presence of erythritol in allantoic and amniotic fluid
b) It has a capsule of polyglutamic acid, which is toxic when injected into rabbits
c) It has 82 polysaccharide capsular types; capsule is antiphagocytic; type 3 capsule (b-d-glucuronic acid polymer) most commonly seen in infected adults
d) It secrets two toxins, A and B, in the large bowel during antibiotic therapy
10. F. tularensis is the bacterium that causes tularemia, a disease not uncommonly seen in hunters. Which one of the following statements best characterizes this bacterium?
a) It produces a toxin that blocks protein synthesis in an infected cell and carries a lytic bacteriophage that produces the genetic information for toxin production
b) It secretes an erythrogenic toxin that causes the characteristic signs of scarlet fever
c) It secrets an exotoxin that has been called “verotoxin” and “Shiga-like toxin”; infection is mediated by specific attachment to mucosal membranes
d) It requires cysteine for growth