Name: Group 1
05.03.2006r.
E. coli causes disease by a variety of different mechanisms. Which of the following
E. coli types is characterized by the presence of LT (heat - labile) and ST (heat - stable) enterotoxin.
EIEC (enteroinvasive E. coli)
ETEC (enterotoxigenic E. coli)
EHEC (enterohemorragic E. coli)
EPEC (enteropathogenic E. coli)
Therapy of E. coli is:
Amoxicillin
Antitoxin
Clarithromycin
Cefotaxime
3. Urinary tract infections are most frequently induced by:
a) Salmonella spp.
b) E.coli
c) Klebsiella spp.
d) Staphylococcus spp.
4. Which antibiotic is most appropriate in the treatment of enteric fever caused by S. typhi:
Ampicillin
Gentamicin
Ciprofloxacin
Flucloxacillion
5. Morbidity of Proteus spp. is:
a) scrub typhus
b) rocky mountain spotted fever
c) urinary tract infections
d) infant pneumonia
6. 45 year - old patient is brought to the emergency room with fever, abdominal pain and acute diarrhea with blood and mucous in the stool. Which of the following bacteria would most likely be isolated from the stool specimen:
a) Enteropathogenic E. coli (EPEC)
b) Shigella flexneri
c) Salmonella enteritidis
d) Proteus mirabilis
7. Sixteen residents in a retirement home have fever, malaise, abdominal pain and skin rash. These residents have taken their meals prepared by the same kitchen. Blood cultures reveal the presence of Salmonella typhi. The primary reservoirs of this organism are:
a) hen's egg
b) dogs and cats
c) people
d) turkeys
8. Endotoxins belong to a class of biological molecules called:
a) mucopolisaccharides
b) proteins
c) peptydoglycans
d) lipopolisaccharides
9. A 48 year-old woman develops a urinary tract infection. The microscopic examination of a urine sample reveals the presence of Gram - negative rods. After antibiotic therapy she developed fever, chills and hypotention. These observations suggest that the patient is responding to the release of bacterial:
a) hyaluronidaze
b) lipopolisaccharide (LPS)
c) peptidoglycan
d) exotoxin
10. E. coli O157 H7 is a newsworthy microorganism that has been isolated from food (meat) with increasing frequency. Its characteristic biology is best described by one of the following statement:
a) It produces protein toxin consisting of two subunits A and B that cause severe spasmatic cough usually in children.
b) It secretes an erythrogenic toxin that causes the characteristic skin rash
c) It secretes an exotoxin that has been called „shiga - like toxin” and „verotoxin”
d) It requires cystein for growth
Name: Group 2
05.03.2006r.
Local lesions induced by Salmonella typhi are localized mainly in:
a) large intestine
b) small intestine
c) kidneys
d) liver
2. What proportion of cases of traveler's diarrhea is caused by enterotoxigenic E. coli?
a) 10%
b)30%
c) 50%
d) 90%
3. Which one of the following investigations is most appropriate in confirming a diagnosis of enteric fever:
a) Elevated C reactive protein (CRP)
b) White cell count indicating a leucopenia
c) Positive Widal test
d) Positive skin test
4. An elderly alcoholic male develops a severe, necrotizing lobar pneumonia. The organism is Lac+ and produces a luxuriant capsule. The most likely agent is:
a) Klebsiella pneumoniae
b) Serratia species
c) Yersinia pseudotuberculosis
d) Pseudomonas aeruginosa
5. Which of the following bacteria is most likely to cause urinary tract infections:
a) Shigella sonnei
b) Salmonella enteritidis
c) Klebsiella spp.
d) Escherichia coli
6. An elderly male presented continous fever, abdominal pain and a rose spot on the skin. Blood culture reveals the presence of S. typhi. Which of the following infections is developing:
a) Bacterial dysentery
b) Gastroenteritis
c) Typhoid fever
d) Scarlet fever
7. Which of the following bacteria produce Shiga - like toxins ( Verotoxins ):
a) Enteropathogenic E. coli (EPEC)
b) Enterotoxigenic E. coli (ETEC)
c) Enterohemorrhagic E. coli (EHEC or VTEC)
d) Enteroinvasive E. coli (EIEC)
8. Which of the following bacteria may cause HUS (hemolytic uremic syndrom)
a) Salmonella enteritidis
b) Enteropathogenic E. coli (EPEC)
c) E. coli O157 H7
d) Klebsiella pneumoniae
9. The final diagnosis of shigellosis is based on clinical symptoms as well as on:
a) culture of stool
b) positive blood culture
c) identification of Shiga toxin in stool
d) PCR for H antigens
10. Non-toxin virulence factor of E. coli is:
a) fimbria - adhesion
b) opacification factor - anti-virulent
c) pili - promote adhesion to mucosal surfaces
d)M-protein - inhibits complement deposition
Name: Group 3
05.03.2006r.
1. Endotoxic shock, linked to the presence of toxic LPS in the cell wall, is most frequently induced by:
a) E.coli
b) Klebsiella spp.
c) Enterobacter spp.
d) Proteus sp.
2. Salmonella enteritidis causes:
a) typhoid fever
b) bacillary dysentery
c) bacterial food poisoning
d) HUS (hemolytic uremic syndrome)
3. Shigellosis is known as one of the common disease in developing countries, it usually might be aquired through:
a) gastrointestinal tract
b) genital tract
c) respiratory tract
d) skin
4. Which one of the following species of Salmonella is not a recognized cause of salmonella food poisoning:
a) S. typhimurium
b) S. derby
c) S. enteridis
d) S. paratyphi
5. An unknown isolate is recognized serologically as S. enteritidis serovar newport. A mutant of the organism has lost region 1 (O-specific polysaccharide) of its lipopolysaccharide. The mutant would be identified as which of the following?
a) S. arizona
b) S. typhi
c) S. newport
d) S. enteritidis
6. A Lac+ glucose-fermenting Gram-negative rod isolated from a previously healthy child with bloody diarrhea is most likely to be:
a) Shigella sonnei
b) Pseudomonas aeruginosa
c) Escherichia coli
d) Salmonella typhi
7. Sixteen residents in a retirement home have fever, malaise, abdominal pain and skin rash. These residents have taken their meals prepared by the same kitchen. Blood cultures reveal the presence of Salmonella typhi. The primary reservoirs of this organism are:
a) hen's egg
b) dogs and cats
c) people
d) turkeys
8. An elderly male develops a severe necrotizing lobar pneumonia. The bacteria cultured from sputum ferment lactose and produce large capsules. The most likely causative agent is:
a) Proteus spp.
b) Shigella spp.
c) EPEC (enteropathogenic E. coli)
d) Klebsiella pneumoniae
9. A 48 year-old woman develops a urinary tract infection. The microscopic examination of a urine sample reveals the presence of Gram-negative rods. After antibiotic therapy she developed fever, chills and hypotention. These observations suggest that the patient is responding to the release of bacterial:
a) hyaluronidaze
b) lipopolisaccharide (LPS)
c) peptidoglycan
d) exotoxin
10. A 2 year - old infant is brought to the emergency room with hemolytic uremic syndrom (HUS) . Which one of the following bacteria would most likely be isolated from a stool specimen
a) ETEC ( enterotoxigenic E. coli)
b) E. coli O157 H7
c) Salmonella enteritidis
d) Shigella sonnei