Figurę 20-29
E. coli. H+ binds first to E-2 outside the celi, followed by lactose. They are released in random order from E-l inside the celi. E-2 must bind both lactose and H' in order to change conformation to E-l, thereby cotransporting these substances into the celi. E-l changes conformation to E-2 when neither lactose nor H+ is bound, thus completing the transport cycle.