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Figurę 3: Immune response induced following VSV treatments. B16gp33-beanng mice (n=9) were infected locally at the tumor site with 5.0 x 108 PFU of WT or mutant VSV on day 7,9 and 11. On day 8 following the first VSV dose, tumor and spleen were harvested and
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Supplemental Figurę 2. MDSC proportions following CVF treatment. B16-beanng mice were treated or not
Figurę 2: Tumor infltration o immune cells following VSV treatment. C57B1/6 mice (n=9) were injected
Figurę 5: Adoptive transfer of activated D8 T lymphocytes limits tumor progress on. B16gp33-beanng m
correlated IFN production and, morę wideły, primary immune responses following VSV infection with My
VSV treatment induces a functional antitumor CTL response. To evaluate the local and systemie T celi
CD8 T cells following VSV infection (Fig. 3a). As expected at this early stage of the immune respons
Figurę 6: Expression of PD-1 and PD-L1 on BI6gp33 cells following VSV infection. B16gp33 cells were
Figurę 7: Expression of MHC-I on B16gp33 cells following VSV infection. (a) B16gp33 cells were infec
VSV treatment promotes immune celi infiltration. Since the generation of an efficient tumor-specific
VIII. ABILITY TO EVADE HOST IMMUNE RESPONSE (CONTD) IMMUNE EVASK)N BY TUMORS F ailure to p
120AB TSP-1 (ng/mL) TSP-1 (ng/mL) Figurę 3.4 : Effect of hexarelin and TSP-1 treatment on MC3T3-E1 c
Figurę 1. Viral replication rates of VSV G mutants. L929 cells were infected at an MOI of (A) 0.1 or
Figurę 2. Effect of VSV G mutants on cellular transcription rates. L929 cells were infected at an MO
Figurę 3. Effect of VSV G mutants on cellular protein synthesis rates. L929 cells were infected at a
Figurę 4. Interferon induction by VSV G mutants. L929 cells were mfected at an MOI of (A) 0.1, (B) 2
Figurę 6. Caspase activation by VSV G mutants. (A) L929 and (B) B16 cells were infected at an MOI of
mutants m both virus availability and robustness of the gp33-specific immune response did not correl
Historically, the complement system nas been considered a ‘complementing’ player m the innate immune
An important mechanism used by malignancies to suppress immune responses against tumor antigens is a
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