4631369900

DONORY TLENKU AZOTU. CZĘŚĆ I 1041

ABSTRACT

Nitric oxide (NO) is a gas substance which plays the role of a carrier of signals in human organism. Molecules of the gas are produced by a single celi and transmit-ted via cellular membranes into another celi where they regulate its function. This is an entirely new mechanism of signal transmission in biological systems.

Recently, it has been demonstrated that the production of nitric oxide from L-arginine is a common biochemical pathway controlling the activity of guanyl cyc-lase. Isomorphic forms of nitric oxide synthase play a role in the regulation of blood yessels tonę, blood flow, activity of platelets, gastrointestinal tract motor activity and reactivity of the respiratory tract. Nitric oxide produced by inducible form of synthase plays a significant role in immunological response and pathophysiological changes present in inflammatory reactioas and shock. Nitric oxide is also produced in neurones of the central and peripheral nervous system.

Currently drugs which could activate or inhibit biochemical reactions concer-ning the release of nitric oxide are being investigated. With these drugs, the role of the system arginine-nitric oxide in physiological and pathological conditions could be cxplaincd. We are looking for donors of nitric oxide in various classes of Chemical compounds. The research conccntrates mainly on the following: O-nitro- and O-nitrosocompounds, S-nitro- and S-nitrosocompounds and 7V-nitro- and A-nitroso-compounds, C-nitro- and C-nitrosocompounds, oximes, heterocyclic NO donor compounds, nitroxyI (HNO/NO-) gencrating compounds, hydroxylamine, A-hydroxy-guanidincs, inorganic NO donors and transition metal nitrosyls.

The tcstcd groups of compounds affect the production of exogenous nitrous oxidc or stimulate its cndogenous production to various degrees. In the course of conductcd studics new applications for well-known drugs appear, and numerous new compounds await rcgistration. One may expect many novel therapeutic options bascd on nitric oxidc.

This study has bccn bascd on Methods in nitric oxide research [1] and current bibliography. In this part of study we present NO donors form the groups: O-nitro-and O-nitrosocompounds, S-nitro- and S-nitrosocompounds and A-nitro- and N-ni-trosocompounds.