4631369949

[narzędzia chemii kombinatorycznej część! 1063

ABSTRACT

Linkers constitute fundamental tools of polymer supported synthesis and com-

bmatonal chemistry Synthesis of any compound on solid support reąuires an effi-

cient method for bmdmg substrate molecules to solid phase and methods for cleava-

_ge of pioduct molecu es from the support after completion of the synthetic sequen-

ce^This rev,ew art.de presents role of linkers in solid-phase synthesis, analogy

between linkers and protectmg groups, and properties of linkers that need to be

cons.dered when planmng synthesis of a particular compound on solid support. Basic

concepts of linker methodology are presented and illustrated with selected exam-

ples\ In addition the role of the linker as protection or activation of functional group

of the substrate and an element controlling regio- or chemoseIectivity is mentioned

The selected, rcprcscntative examples of classical and recently elaborated linkers

are elassified accordmg to the conditions of cleavage. These include acid sensitive

basc or nuclcophile scnsitive, photolabile, safety catch linkers, traceless linkers and cyclatiYc clcavagc linkers.